[PDF] Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression | Semantic Scholar (2024)

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@article{Won2016StressTA, title={Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression}, author={Eunsoo Won and Yong-Ku Kim}, journal={Current Neuropharmacology}, year={2016}, volume={14}, pages={665 - 673}, url={https://api.semanticscholar.org/CorpusID:7821197}}
  • E. Won, Yong-Ku Kim
  • Published in Current Neuropharmacology 1 October 2016
  • Medicine, Psychology

This review focuses on the interaction between stress, the autonomic nervous system and the immune system which can cause imbalances in the kynurenine pathway, which may ultimately lead to major depressive disorder.

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198 Citations

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The interesting fact is that not only can direct anti-inflammation treatment improve neuroinflammation, but so can stress reduction or pharmacological antidepressants, and this presents the direction of future development of stress-related neuro inflammation drugs.

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Central regulation of stress-evoked peripheral immune responses
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This work comprehensively summarizes studies that have employed retrograde tracing to define neurocircuits linking the brain to the bone marrow, spleen, gut, adipose tissue and liver and outlines the neural circuits through which the CNS regulates immune cell function in peripheral tissues in response to stress.

  • 9
Immunological Aspects of Depressive Disorder – The Review
    J. VojvodićG. MihajlovićA. AndonovM. MarkovićJ. DjordjevicP. Vojvodić

    Medicine, Biology

    Serbian Journal of Experimental and Clinical…

  • 2019

The aim of this paper is to analyze the current knowledge on the role of immune mechanisms in the pathogenesis of depression and to demonstrate neuroprotective role of autoreactive and regulatory T cells in prevention of depression.

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Neuroimmune Imbalances and Yin-Yang Dynamics in Stress, Anxiety, and Depression.
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    Methods in molecular biology

  • 2018

The recognition of the neuroimmune imbalances and the restoration of the Yin-Yang dynamical balances need to become a high priority toward the development of dynamical systems medicine for psychiatric diseases including depression and schizophrenia.

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A Potential Interface between the Kynurenine Pathway and Autonomic Imbalance in Schizophrenia
    Alexandra BükiG. KékesiG. HorváthL. Vécsei

    Medicine, Psychology

    International journal of molecular sciences

  • 2021

The present review gathers autonomic disturbances, the impaired kynurenine pathway in schizophrenia, and the effects of kynurenic acid pathway on autonomic functions and the possible therapeutic options are discussed.

Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression
    E. WonKyoung-Sae NaYong-Ku Kim

    Medicine, Psychology

    International journal of molecular sciences

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The ability of melatonin to suppress inflammatory responses through immunological and non-immunological actions, thus influencing neuroinflammation and neurotoxicity, along with subsequent alterations in brain regions that are implicated in depression, can be demonstrated by the antidepressant-like effects ofmelatonin.

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The vulnerability-stress-inflammation model matches with this view as stress may increase proinflammatory cytokines and even contribute to a lasting proinflammatory state.

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