[PDF] Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression | Semantic Scholar (2024)

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@article{Won2016StressTA, title={Stress, the Autonomic Nervous System, and the Immune-kynurenine Pathway in the Etiology of Depression}, author={Eunsoo Won and Yong-Ku Kim}, journal={Current Neuropharmacology}, year={2016}, volume={14}, pages={665 - 673}, url={https://api.semanticscholar.org/CorpusID:7821197}}
  • E. Won, Yong-Ku Kim
  • Published in Current Neuropharmacology 1 October 2016
  • Medicine, Psychology

This review focuses on the interaction between stress, the autonomic nervous system and the immune system which can cause imbalances in the kynurenine pathway, which may ultimately lead to major depressive disorder.

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The aim of this paper is to analyze the current knowledge on the role of immune mechanisms in the pathogenesis of depression and to demonstrate neuroprotective role of autoreactive and regulatory T cells in prevention of depression.

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The recognition of the neuroimmune imbalances and the restoration of the Yin-Yang dynamical balances need to become a high priority toward the development of dynamical systems medicine for psychiatric diseases including depression and schizophrenia.

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A Potential Interface between the Kynurenine Pathway and Autonomic Imbalance in Schizophrenia
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The present review gathers autonomic disturbances, the impaired kynurenine pathway in schizophrenia, and the effects of kynurenic acid pathway on autonomic functions and the possible therapeutic options are discussed.

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The ability of melatonin to suppress inflammatory responses through immunological and non-immunological actions, thus influencing neuroinflammation and neurotoxicity, along with subsequent alterations in brain regions that are implicated in depression, can be demonstrated by the antidepressant-like effects ofmelatonin.



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